The results showed that wild-type IFITM1 (IFITM1w) markedly inhibited EphA2-mediated EBV infection, while single mutations of IFITM1 (IFITM1m1 or IFITM1m2) slightly impaired this inhibitory effect, and dual mutations of IFITM1 (IFITM1m1+2) completely abolished the inhibition of EBV infection (Fig. 4b,c, NP69 and HEK293). This evidence concerns the gene EPHA2 and Epstein-Barr virus infection.