We confirmed that CARM1 KD or inhibition reduced the proliferation of AML cells (Supplementary Fig. 15A), inducing G0/G1 cell cycle arrest (Supplementary Fig. 15B) and differentiation, and to a lesser degree apoptosis (Supplementary Fig. 15C), consistent with our previous report24. Here, CARM1 is linked to acute myeloid leukemia.