JAK2 and myeloproliferative neoplasm: We also examined the UKE-1 cell line, derived from a myeloproliferative neoplasm patient that carries a bi-allelic JAK2-V617F mutation50, and show that UKE-1 cells also have a high level of JAK2 auto-phosphorylation, as well as CARM1-Y149/Y334 phosphorylation (Fig. 2D).