Autoreactive IgE titers in SLE patients are associated with disease activity, increased basophil activation (CD203c), basophil migration abilities (increased CD62L, PTGDR-2, and CXCR4 expressions), and basopenia that reflects their accumulation into SLO14,15,17–22. The gene discussed is IGHE; the disease is systemic lupus erythematosus.