Of note, the analysis of non-TFH CD4 + T helper cells (defined as CD45+ CD19– TCRβ+ CD8α– CD4+ CD44+ CXCR5 – cells) revealed that basophil depletion in lupus-like models impacted only the TH2 cell compartment in both mouse models (Supplementary Fig. 6e–k). Here, CD8A is linked to systemic lupus erythematosus.