LYN and systemic lupus erythematosus: Here, in agreement, efficient DT-mediated basophil depletion (Fig. 2e, f and Supplementary Fig. 2a–c, j, l) resulted in a dramatic decrease in autoreactive IgG antibody titers in both pristane-induced and Lyn–/– lupus-like mouse models (Fig. 2g, h).