To disclose the underlying association between these two phenomena, differentially expressed genes from the transcriptome sequencing results after HIF-2α knockdown, lipid metabolism-related genes, survival-related genes and differentially expressed genes between normal and tumor samples in TCGA dataset; three genes were selected for further analysis: MED15, ACLY, and TRIB3 (Fig. 1A). This evidence concerns the gene ACLY and neoplasm.