The results showed that the MED15-mediated transcriptional activation of SREBP pathway members (SREBP1, SREBP2 and PLK1) was decreased in HIF-2α knockdown cells compared with control cells, suggesting that HIF-2α can independently promote the expression of SREBP1, SREBP2 and PLK1 in ccRCC. This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.