We found that MED15 knockdown resulted in a decrease in SREBP-targeted gene (FASN, SCD1, ACLY, and ACC1) expression, and MED15 overexpression increased the expression of SREBP-targeted genes (FASN, SCD1, ACLY, and ACC1) in ccRCC. Here, FASN is linked to nonpapillary renal cell carcinoma.