ALAS2 and myeloid leukemia: Consistent with these forward genetic results, the gene expression patterns in ∼10,000 patient tumors from the Genotype-Tissue Expression (GTEx) (Lonsdale et al, 2013; The GTEx Consortium et al, 2015) and The Cancer Genome Atlas (TCGA) (Cancer Genome Atlas Research Network et al, 2013) datasets show that ALAS2 expression is absent in most tumors except myeloid leukemias (Fig S2B).