Several proinflammatory cascades that drive neuroinflammation in AD have been highlighted, such as the nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and type 1 interferons (65, 66, 67, 68). Here, NLRP3 is linked to Alzheimer disease.