The associations of phylum Actinobacteria, class Actinobacteria, body mass index (BMI), waist to hip ratio, fasting insulin, and smoking initiation with CRC risk were attenuated in the multivariable Mendelian randomization analyses, with adjustment for metabolites (Figure 4), whereas the association of leisure television watching with CRC became stronger (Supplementary Figure 3, available online). The gene discussed is INS; the disease is colorectal carcinoma.