These mediators encompass platelet-derived growth factor (PDGF), TGF-β1, IGF-1, EGF, VEGF, FGF, and hepatocyte growth factor (HGF).44 Among these, EGF and fibronectin play crucial roles in the proliferation and migration of epithelial cells, while PDGF, HGF, and FGF stimulate cell proliferation.45 Different preparations, namely PRP, PRGF, and platelet lysate, have been used for treatment of dry eye, PED, postrefractive dry eye, chemical injuries, and GVHD.46–48. The gene discussed is HGF; the disease is dry eye syndrome.