RARA and acute myeloid leukemia: In addition, we found that GATA2 and PML::RARA bound in close proximity (with binding sites that overlapped by at least 1 bp) at 253 regions in the genome, including the Osbpl5 locus (Fig. 5 A and E and SI Appendix, Fig. S11D), as an example that has been implicated in AML biology (51, 52).