One of these genes was MMP2 (Fig. 2B and SI Appendix, Fig. S7B), which has previously been implicated in AML pathogenesis (39), and which also shows a 173-fold increase in expression in human APLs compared to healthy donor promyelocytes (SI Appendix, Fig. S7F) (40). Here, MMP2 is linked to acute myeloid leukemia.