PML and neoplasm: We previously established that inactivation of Gata2 after PML::RARA expression leads to an increased frequency of knockout Gata2 alleles within 4 wk (12); in that context, PML::RARA establishes the aberrant self-renewal phenotype, and Gata2 appears to act as a tumor suppressor to limit the proliferative stress caused by PML::RARA.