It is well known that BMPs commonly accumulate in both drug-induced and genetic lysosomal storage disorders (Gruenberg, 2020; Showalter et al., 2020; Hullin-Matsuda et al., 2014), and due to their cone-shaped structure BMPs can contribute to significant membrane asymmetry that impacts intracellular lipid sorting, apoptosis, and autophagic flux (Gruenberg, 2020; Showalter et al., 2020; Hullin-Matsuda et al., 2014). Here, CLN5 is linked to lysosomal storage disease.