All germline RAD51C/D tumors had high levels of nuclear BRCA1 foci, which excluded potential concomitant epigenetic silencing of BRCA1 as the origin of HRD,14 except for 1 RAD51C carrier with low levels of BRCA1 foci likely due to a concomitant tumor BRCA1 PV (eFigure 2 in Supplement 1). Here, RAD51C is linked to neoplasm.