RAD51D and breast cancer: In this study of 9507 index patients, the prevalence of an RAD51C/D PV was 1.0%, slightly higher than in population-based studies.1,2 Almost half of the index patients had no family history of breast cancer or ovarian cancer, compatible with the moderate cancer risk associated with these gene alterations.3 One variant (RAD51D c.694C>T) was highly prevalent in our cohort (57.1%), and although it had previously been reported elsewhere,34 its high frequency may suggest a founder origin.