The results revealed a heterozygous variant in MSH3 (c.606G > A, p.Cln202 =), which was interpreted as likely benign in ClinVar [8], and no difference in MSH3 expression was observed between the normal mucosa, adenomas, and carcinomas using tissue immunostaining (Fig. 3) of formalin-fixed, paraffin-embedded specimens with a rabbit monoclonal anti-MSH3 antibody (ab111107; Abcam, Cambridge, UK), performed as described previously [9]. This evidence concerns the gene MSH3 and carcinoma.