For example, overexpression of G6PD upregulated mRNA expression of NOX gp91phox and p22phox subunits, potentiating ROS production and oxidative damage in mouse pancreatic β cells and thymic lymphoma cells, which provided evidences for NOX-mediated oxidative stress by excess intracellular NADPH (Tome et al. 2006; Lee et al. 2011). This evidence concerns the gene G6PD and thymus lymphoma.