TG and hepatocellular carcinoma: Previous studies confirmed the activation of the thyroid pathway appeared to be stimulatory for the humoral immunity in anadromous fish (Bitencourt et al. 2012; Farkas et al. 2008; Karkhaneh et al. 2019; Liu and Lv 2008; Yilmazer et al. 2003; Zwollo 2018) and complement could be up-regulated by thyroid hormones in human hepatocellular carcinoma cell lines (Lin et al. 2003).