VEGFA and neoplasm: Research elucidates that the C6 tumor facilitates this breakdown via the secretion of factors like vascular endothelial growth factors (VEGF) and matrix metalloproteinases (MMPs), which collectively undermine the endothelial tight junctions and degrade the basal lamina, thereby compromising the barrier function (Feng et al. 2022; Matsuno et al. 2022).