IDH1 and acute myeloid leukemia: In particular, these studies implicate epigenetic regulators as key factors in AML pathogenesis, including DNMT3A, TET2, IDH1/2, ASXL1, and the cohesin complex (Chan and Majeti, 2013; Ley et al., 2010; Delhommeau et al., 2009; Gross et al., 2010; Abdel-Wahab et al., 2012; Kon et al., 2013).