PLK1 and neoplasm: This outcome is in line with various studies that have examined the difference following inhibition of PLK1 in cancer cells and non‐cancer cells.[27, 31] To confirm that FNP1 was primed specifically for silencing gene expression in conditions mimicking the tumor microenvironment rather than at pH 7.4 – as occurs in blood and healthy tissues, we measured the translational effect of gene silencing for Plk1 when D425 and HCM3 cells were transfected in OptiMem pH 7.4 (Figure 5F,G).