Although the etiology of IBD is not yet fully known, it has been suggested that the onset and aggravation of the intestinal inflammation seem to be due to the dysregulation of the body’s immune responses with a parallel increase of pro-inflammatory cytokines, including IL-1β, IL-6, IL-8, TNF-α, and so on (51, 52). Here, CXCL8 is linked to irritable bowel syndrome.