Compared to the NC group, the expression of hepatic lipogenesis genes PPARγ, hepatic bile acid biosynthesis genes CYP7A1, hepatic inflammation genes Mcp-1, Tlr2, Tlr4, IL-10 upregulated significantly, while the expression of hepatic lipid oxidation genes Cpt2, Acox1, Ppargc1a, hepatic lipolysis gene Lipe, Pnpla2 and Fabp5, ileum SCFAs receptors SLC5A8, and intestinal permeability gene Occludin and ZO-1 downregulated significantly in HD. The gene discussed is FABP5; the disease is Huntington disease.