Eighty patients with IDD, including 28 RRMS (18 females, mean (±SD) age: 45.5 (±11.8) years), 24 AQP4 + NMOSD (18 females, mean age: 49.9 (±12.7) years) and 28 MOGAD (19 females, mean age: 36.4 (±17.1) years) patients and 32 HCs were enrolled in the study. This evidence concerns the gene AQP4 and intervertebral disk degenerative disorder.