Additionally, supporting the role of impaired metabolism and ROS in male infertility, clinical studies have reported that 30% of such conditions are associated with low testicular level of glutathione peroxidase 4 (GPX4), a unique intracellular antioxidant enzyme that can directly reduce lipid peroxidation and inhibit ferroptosis outcomes 14. The gene discussed is GPX4; the disease is male infertility.