HSF1 and breast cancer: In the publicly-available dataset for HER2-positive breast cancer patients, mRNA expression levels of HSF1, HSP90 (HSP90AA1) and HSP70 (HSPA1A) are simultaneously upregulated in tumor tissues relative (p < 0.05, Figure 1A-C), with a substantial positive correlation between HSF1 and either HSP90 (p < 0.0001, Figure 1D) or HSP70 (p < 0.0001, Figure 1E).