INSIG2 and cardiovascular disorder: Figure 4C is the graphical summary, showing the inhibited engulfment and phagocytosis of red blood cells, EIF2 signaling, and synthesis of ATP while the induced ASXL1 (ASXL Transcriptional Regulator 1, for chromatin remodeling), HSD17B4 (hydroxysteroid-17-beta-dehydrogenase 4, for peroxisomal fatty acid beta-oxidation), and INS1G2 (insulin induced protein 2, associated with cardiovascular disease).