In step-flow chamber, d-flow markedly inhibited MerTK expression while induced endothelial dysfunction, indicating increased expression of pro-inflammatory signaling such as NLRP3 inflammasome (NLRP3, pro-IL-1β, and cleaved IL-1β), TNF-α, and NF-κB (Figure 1L). The gene discussed is TNF; the disease is endothelial dysfunction.