We found several novel activation pathways between d-flow and atherosclerosis (Figure 2B), such as Zn2+-dependent inner mitochondrial membrane metalloendopeptidase OMA1, SR 1078 (a selective agonist of RORα and RORγ) and EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). Here, EIF2AK3 is linked to atherosclerosis.