We performed big data analytics (epigenetic maps and tissue GTEx), RNA-seq and proteomics to find clues to unique pathways of MerTK in d-flow-mediated endothelial dysfunction and atherosclerosis, gaining insight into mechanisms by which endothelial MerTK restoration confer protection from impaired efferocytosis and atherosclerosis. Here, MERTK is linked to endothelial dysfunction.