GLI1 and Hepatic fibrosis: These data demonstrated that the suppression of HPC-originated DR by inhibition of Gli1 attenuated hepatic fibrosis, since ductular reactive cells may stimulate HSC/myofibroblast activation through secretion of multiple proinflammatory and profibrogenic factors, which was evidenced by co-culture of WB-F344 cells with LX-2 cells.