CD8A and neoplasm: The reduction in the tumor volumes and increases in the M1-macrophage population and CD8/Treg ratio by IL4R-Abx were higher than those by Abx given at a higher dose (10 mg/kg body weight), while the decline in tumor weights, the number of metastatic nodules, and the M2-macrophage and MDSC population by IL4R-Abx was equivalent to those of Abx given at a higher dose (Figure 8E-K).