HMGB1 and neoplasm: The study findings demonstrated that IL4R targeting allowed Abx to improve M2-macrophage reprogramming into an M1-like phenotype through the ROS-HMGB1-TLR4 axis and enhance the antitumor immunity via increasing immune-stimulatory cells while decreasing immune-suppressive cells in the tumor microenvironment, contributing to the inhibition of tumor growth and metastasis in tumor-bearing mouse models (Figure S17).