In the pancreatic tumor tissues of KPC mice, IL4R-Abx increased the M1-macrophage population (Figure S11C) and decreased the MDSC population (Figure S11F) at higher levels than Abx, while the M2-macrophage population (Figure S11D) and CD8+ T-cell/Treg ratio (Figure S11E) were equivalent to those of Abx. The gene discussed is CD8A; the disease is pancreatic neoplasm.