CD8A and neoplasm: In line with the substantially increased density of effector molecule-expressing TILs and better tumor control of irradiated and abscopal tumors (see Figure 1B-C), analyses of M8-tetramer+ CD8+ T cell subsets of exhausted cells revealed that the effector-like “transitory” (TIM3+ CD101- PD1+) population predominantly increased among the tumor-specific TILs of both primary and secondary tumor in hRT/lena-treated compared to hRT-treated mice (Figure 6D-E).