The concerted increase in tumor-infiltrating DCs, non-terminally differentiated exhausted T cells, and MECA-79+ TA-HECs found in the non-irradiated tumors is also consistent with published findings showing that DCs are required for forming MECA-79+ HEVs 56 and that CD8+ T cells are important regulators of TA-HEVs in a feed-forward loop 54. Here, CD8A is linked to neoplasm.