As shown in Figure S5A-C, hRT/lena treatment resulted in a statistically significant increase of tumor-specific CD8+ T cells with a memory phenotype (CD44+ KLRG1- CD127+ CD62L+) in the secondary tumor of B16-CD133 tumor-bearing mice compared to hRT monotherapy; in the primary tumor a trend towards increased numbers was observed. The gene discussed is PROM1; the disease is neoplasm.