INS and type 2 diabetes mellitus: In the context of T2D, the modulation of the CSN with kilohertz high frequency alternating current (KHFAC, 50KHz, 2 mA), i.e., continuous electrical blockade of the CSN, was shown to have the ability to restore insulin sensitivity and glucose tolerance in T2D rats after 1 week, effects that were maintained during the 9 weeks of blockade (Figure 2 and Table 1; Sacramento et al., 2018).