Dhabhar et al. (2009) showed a higher IL-6/IL-10 ratio, and the apparent absence of a counterbalancing, immunoregulatory increase in IL-10 in response to elevated IL-6 concentration contributes to the pro-inflammatory status what suggested to be associated with MDD. IL-10 lower level on admission is considered as a predictor of post-stroke depression (Chi et al., 2021). Here, IL10 is linked to major depressive disorder.