F8 and hemophilia: To improve diagnosis in women and girls with hemophilia and carriers, the International Society on Thrombosis and Hemostasis (ISTH) Scientific and Standardization Committee (SSC) approved a new nomenclature that defines five clinical categories for hemophilia carriers based on FVIII plasma levels: woman/girl with mild hemophilia when factor levels are >0.05 and < 0.40 IU/mL, moderate hemophilia when factor levels are 0.01–0.05 IU/mL, or severe hemophilia with factor levels <0.01 IU/mL.