Indeed, female patients with FVIII or FIX levels <0.40 IU/mL should be considered and managed as other patients with hemophilia, and clinicians should be aware that bleeding may also occur in carriers with FVIII/FIX levels of ≥0.40 IU/mL, with impact on their health-related quality of life. The gene discussed is F8; the disease is hemophilia.