Volcano plot representation (Figure 2A) showed a significant deficit of plasmacytoid dendritic cells (pDC) (C-26) in EoE patients and an expansion of CD4-CD8- and early effector CD8+ T-cells (Clusters 37 and 69) at the time of disease diagnosis (Figure 2B). This evidence concerns the gene CD4 and eosinophilic esophagitis.