GB is present in synovial and cerebrospinal fluids of respectively rheumatoid arthritis and multiple sclerosis (MS) patients while it is also present in the bronchoalveolar lavage from chronic obstructive pulmonary disease (COPD) patients, with GB expressing CD8+ T cells directly correlated with progression and disability in MS (28, 159, 178–182). Here, CD8A is linked to chronic obstructive pulmonary disease.