While our group has previously shown that the MHC ll protein HLA-DRB1 is directly fucosylated and that this post-translational modification promotes its cell surface trafficking and accumulation to stimulate CD4+T cell-mediated anti-tumor immune responses, the fucosylation-mediated regulation of other MHC proteins on tumors and immune cells has yet to be established, and future studies are needed. This evidence concerns the gene HLA-DRB1 and neoplasm.