Recent studies by Rentsendorj et al., and Qiu et al., beautifully demonstrate using the ADtg and 5XFAD mouse models for AD, respectively roles for specific populations of SPP1+/- expressing monocytes, resident microglia and/or macrophages in the phagocytosis of amyloid and speculate about a role for inflammasome signaling (116, 117). Here, SPP1 is linked to Alzheimer disease.