SOAT1 and primary cutaneous T-cell non-Hodgkin lymphoma: Recent research, has provided insight into this process, showing how primary malignant T cells induce significant changes in the expression of skin barrier proteins in CTCL through cytokine-mediated JAK/STAT signaling, highlighting the intricate relationship between malignant T cell activity and compromised skin barrier integrity in the disease pathology of CTCL (30).