In the advanced stage of sepsis, CD4+ T cells, CD8+ T cells and monocytes are reduced to varying degrees, and immunosuppression is aggravated (Riedemann, Guo & Ward, 2003; Barochia et al., 2010), which increases the severity of the disease (Xiufen, Shunyao & Qingming, 2018). The gene discussed is CD8A; the disease is Sepsis.