However, a drastic change in the proportion of polarized macrophages was found in humans and mice with allergic asthma or lung inflammation; MHCII-hi macrophages (M1) and CD206+ macrophages (M2) both increased, but interleukin (IL)-10+ macrophages decreased (Draijer et al., 2022) suggesting a relationship between asthma and macrophages. This evidence concerns the gene IL10 and allergic asthma.