Consequently, the genetic protection against an infectious disease of an individual may determine the susceptibility to a life-threatening disease, and evolutionary genetic linkages through Angiotensin-Converting Enzyme 2 (ACE2) polymorphisms have been reported as an explanation for the lower burden of COVID-19 in malaria-endemic regions (Napoli & Nioi, 2020). This evidence concerns the gene ACE2 and COVID-19.