Surprisingly, HSP70 also exists in the form of EVs in peripheral blood or urine samples of patients with lung cancer (24, 27), NSCLC (30–33), breast cancer (24, 27, 39), ovarian cancer (27), glioblastoma (30, 64), and melanoma (50), protecting it from the phospholipid bilayer membrane and making it more stable. Here, HSPA1A is linked to melanoma.