Surprisingly, HSP70 also exists in the form of EVs in peripheral blood or urine samples of patients with lung cancer (24, 27), NSCLC (30–33), breast cancer (24, 27, 39), ovarian cancer (27), glioblastoma (30, 64), and melanoma (50), protecting it from the phospholipid bilayer membrane and making it more stable. The gene discussed is HSPA1A; the disease is non-small cell lung carcinoma.