Vitamin K2 (MK-7) supplementation is associated with significantly decreased insulin levels, fasting glucose, and HbA1c levels in individuals with T2DM compared to controls. Higher concentrations of secondary bile and short-chain fatty acids were found in the vitamin K2 supplementation group, along with increased richness of the genera biosynthesizing these metabolites. The gene discussed is INS; the disease is type 2 diabetes mellitus.