Following a structured low-calorie formula diet for 6 weeks, followed by a 9-week food reintroduction period, can greatly increase the gut microbiota in patients. All patients had a significant decrease in HbA1c, fasting glucose, and insulin levels by the end of the trial. There was a significant decrease in levels of Collinesella in all patients, which indicated lower levels of atherosclerosis and plaque buildup. The gene discussed is INS; the disease is atherosclerosis.