Obesity and diets high in UPFs are associated with alterations in the composition of the gut microbiota, termed dysbiosis, which can promote inflammation through various mechanisms, including elevated levels of inflammatory markers such as C-reactive protein (CRP) and IL-6 (an indicator of systemic inflammation), and increased oxidative stress that can trigger inflammatory responses and contribute to endothelial dysfunction, immune cell activation, plaque formation, and destabilization [17,18,33,34]. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.