GPT and congestive heart failure: A retrospective analysis of the PARADIGM-HF trial revealed that elevated levels of alanine aminotransferase (ALT) were linked to a poorer prognosis in patients with chronic heart failure with reduced ejection fraction (HFrEF), as well as total bilirubin, while aspartate aminotransferase (AST) did not show a significant association with prognosis (22).