Hypomethylation and overexpression of neuromedin B was associated with improved survival outcomes.100 Hypomethylation and overexpression of chitinase-3-like protein 1 (CHI3L1), S100 calcium-binding protein A4 (S100A4), lysyl oxidase (LOX), S100 calcium-binding protein A11 (S100A11) were associated with poor survival outcomes.100 Demethylation in C-X-C chemokine receptor type 4 (CXCR4), T-box transcription factor 18 (TBX18), Sp5 transcription factor (SP5) and transmembrane protein 22 (TMEM22) were associated with tumour initiation and progression in glioblastoma.101. This evidence concerns the gene S100A4 and glioblastoma.