IDH1 and neoplasm: TAMs comprise 30% of cells in glioblastoma.119 Their abundance favours tumour progression.120,121 While TAMs with a type 1 macrophage phenotype are traditionally pro-inflammatory and can eradicate organisms, TAMs expressing the M2 phenotype are immunosuppressive in nature.122 Predominance of the M2 phenotype in the tumour microenvironment has been associated with worse prognosis in IDH-wt glioblastoma.123-126