As a tumour suppressor gene, the inactivation of both alleles of NF1 are necessary for the loss of neurofibromin and subsequent tumour formation.83,84 NF1 deactivation is associated with the chemotaxis and infiltration of tumour-associated macrophages (TAMs) and microglia in the immune microenvironment of IDH-wt glioblastomas.41 Longitudinal transcriptomic analysis showed that this phenotype of expression is present in 55% of glioblastoma cases.41 The population size of M2 macrophages in the immune microenvironment was further associated with relapse post radiotherapy and tumour resistance.41 Here, IDH1 is linked to neoplasm.