SP5 and neoplasm: Hypomethylation and overexpression of neuromedin B was associated with improved survival outcomes.100 Hypomethylation and overexpression of chitinase-3-like protein 1 (CHI3L1), S100 calcium-binding protein A4 (S100A4), lysyl oxidase (LOX), S100 calcium-binding protein A11 (S100A11) were associated with poor survival outcomes.100 Demethylation in C-X-C chemokine receptor type 4 (CXCR4), T-box transcription factor 18 (TBX18), Sp5 transcription factor (SP5) and transmembrane protein 22 (TMEM22) were associated with tumour initiation and progression in glioblastoma.101