Thus, the IL6 rs1800795-C (promoter) genomic variant is associated with the predisposition to depression onset in Australian (Tartter et al., 2015) and Spanish populations (Udina et al., 2013), and also correlates with increased sensitivity to pain and stress perception in a Hungarian population of depressed patients (Kovacs et al., 2016). Here, IL6 is linked to major depressive disorder.