It has also been demonstrated that a 2–3-fold increase in endogenous GDNF expression triggers schizophrenia-like conditions (including the expression of relevant genes and behavioral responses) and also imbalance the dopamine content between the prefrontal cortex and striatum (Ross et al., 2008; Liao et al., 2012; Wearne and Cornish, 2018). This evidence concerns the gene GDNF and schizophrenia.