Then, in order to further explore whether SUV39H1 knockout could improve the tumoricidal capacity of CAR‐T cells, SUV39H1‐disrupted, CAR‐transduced T cells and unedited CAR‐T cells were respectively infused into B cell acute lymphoblastic leukemia mouse models to compare the difference in efficacy. Here, SUV39H1 is linked to B-cell acute lymphoblastic leukemia.