Some researchers screened MSI2 from cell stemness genes by comparing highly invasive lung cancers with less invasive lung cancers in NSCLC, and confirmed the highest expression level in metastatic lung cancers, followed by primary lung cancers, and lowest in normal lung tissues by clinical samples, thus suggesting that MSI2 is highly correlated with EMT in NSCLC by regulating TGF‐β and inhibiting claudins ultimately promote the invasive metastasis of NSCLC. The gene discussed is TGFB1; the disease is lung carcinoma.