IRS1 and Insulin resistance: Yunpi Heluo decoction improved insulin resistance in Zucker diabetic fatty rats by reducing miR-29a-3p expression causing increased Irs1 expression, a target of miR-29a-3p (Mao et al., 2019), thereby increasing the protein expression of IRS1, protein kinase B, and pyruvate dehydrogenase lipoamide kinase isozyme 1 (PDK1) (Mao et al., 2019).