PRL and cancer: Our findings reveal neuroactive ligand-receptor interactions, chemical oncogenic receptor activation, diabetic cardiomyopathy, cAMP signaling pathway, inflammatory mediator regulation of TRP channels, insulin resistance, proteoglycans in cancer, serotonin Energy synapse, AGE-RAGE signaling pathway, EGFR tyrosine kinase inhibitor resistance, and prolactin signaling pathway appeared both in the top 10 important signaling pathways in GO analysis and KEGG analysis.