Our findings reveal neuroactive ligand-receptor interactions, chemical oncogenic receptor activation, diabetic cardiomyopathy, cAMP signaling pathway, inflammatory mediator regulation of TRP channels, insulin resistance, proteoglycans in cancer, serotonin Energy synapse, AGE-RAGE signaling pathway, EGFR tyrosine kinase inhibitor resistance, and prolactin signaling pathway appeared both in the top 10 important signaling pathways in GO analysis and KEGG analysis. This evidence concerns the gene INS and cancer.