TP53 and cancer: Moreover, the KEGG pathway analysis highlighted the involvement of the common target genes in a wide range of biological pathways, including pathways in cancer (hsa05200), TNF-α signaling pathway (hsa04668), PI3K-Akt signaling pathway (hsa04151), apoptosis (hsa04210), p53 signaling pathway (hsa04115), IL-17 signaling pathway (hsa04657), and C-type lectin receptor signaling pathway (hsa04625), among others (Figure 4F).