PMAIP1 and memory impairment: Zhu et al. reported that EA at acupoints (GV14 and GV20) at a frequency of 4 Hz can protect against neuronal apoptosis in the hippocampal CA1 area and attenuate memory impairment; these effects are partly mediated by the suppression of p53/Noxa-related signaling in the chronic phase after GCI (31).