As a perspective of this study, it is contemplated to measure the plasma levels of the SIRT1 protein, especially in patients with the GG genotype for the genetic variants of the rs7895833 and rs1467568 SIRT1, and to assess whether SIRT1 could be used as a protein marker of diagnosis in various metabolic diseases in the Mexican population. The gene discussed is SIRT1; the disease is metabolic disease.