The male sex carrying the SNV rs7895833 (G allele) presented a lower BMI than subjects without the this SIRT1 SNV and subjects carrying the SIRT1 SNV rs1467568 (G allele) showed a non-risk effect with a 34% probability of not presenting hyperbetalipoproteinemia, where women carrying the rs1467568 had lower levels of total cholesterol, triglycerides, and LDL cholesterol than women without this SNV. Here, SIRT1 is linked to familial hypercholesterolemia.