Because in Mexico there is a high rate of obesity, especially among young adults, for whom this disease can affect their health for a longer period of time (Sánchez-Villegas et al., 2010; Cheng et al., 2016), our objective was to evaluate two genetic variants of SIRT1, the rs1467568 and rs7895833, and determine their association with cardiometabolic risk factors in a young adult population from the northeastern region of Mexico. The gene discussed is SIRT1; the disease is obesity disorder.